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Aspartame Causes Cancer in Rats

Copyright 2005 Daily News Central

Rats given varying doses of aspartame -- the second most
widely used artificial sweetener in the world --
experienced a statistically significant increase in the
incidence of malignant tumors, lymphomas and leukemias in a
study slated for publication in Environmental Health
Perspectives.

By Rita Jenkins Category: 0

Submit your Articles Here!

Copyright 2005 Daily News Central

Rats given varying doses of aspartame -- the second most
widely used artificial sweetener in the world --
experienced a statistically significant increase in the
incidence of malignant tumors, lymphomas and leukemias in a
study slated for publication in Environmental Health
Perspectives.

The study's authors are calling for an "urgent
re-evaluation" of the current guidelines for consumption of
this compound.

"Our study has shown that aspartame is a multipotential
carcinogenic compound whose carcinogenic effects are also
evident at a daily dose of 20 milligrams per kilogram
(mg/kg) of body weight," the authors write, "notably less
than the current acceptable daily intake for humans."
Currently, the acceptable daily intake for humans is set at
50 mg/kg in the United States and 40 mg/kg in Europe.

More Than 200 Million People

Aspartame is found in more than 6,000 products, including
carbonated and powdered soft drinks, hot chocolate, chewing
gum, candy, desserts, yogurt and tabletop sweeteners, as
well as some pharmaceutical products like vitamins and
sugar-free cough drops.

More than 200 million people worldwide consume the
sweetener. It has been used for more than 30 years, having
first been approved by the Food and Drug Administration
(FDA) in 1974.

Earlier research on the carcinogenicity of aspartame
performed by its producers has been negative.

In the latest study, investigators administered aspartame
to rats by adding it to a standard diet. They began
studying the rats at eight weeks of age and continued until
the spontaneous death of each rat. This study followed more
animals over a longer period than did earlier research.

Treatment groups received feed that contained
concentrations of aspartame at dosages simulating human
daily intakes of 5,000, 2,500, 500, 100, 20 and 4 mg/kg
body weight. Groups consisted of 100 males and 100 females
at each of the three highest dosages, and 150 males and 150
females at all lower dosages, as well as controls.

The experiment ended after the death of the last animal at
159 weeks. At spontaneous death, each animal underwent
examination for microscopic changes in all organs and
tissues, a process different from the aspartame studies
conducted 30 years ago and one that was designed to allow
aspartame to fully express any carcinogenic potential.

Extensive Evidence of Malignancies

The treated animals showed extensive evidence of malignant
cancers, including lymphomas, leukemias and tumors at
multiple organ sites in both males and females.

The increase in lymphomas and leukemias may be related to
one of the metabolites in aspartame -- namely methanol --
which is metabolized in both rats and humans to
formaldehyde, the authors speculate. Both methanol and
formaldehyde have shown links to lymphomas and leukemias in
other long-term experiments.

"In our opinion, previous studies did not comply with
today's basic requirements for testing the carcinogenic
potential of a physical or chemical agent, in particular
concerning the number of rodents for each experimental
group (40-86, compared to 100-150 in the current study) and
the termination of previous studies at only 110 weeks of
age of the animals," the authors conclude.


----------------------------------------------------
Rita Jenkins is a health journalist for Daily News Central,
an online publication that delivers breaking news and
reliable health information to consumers, healthcare
providers and industry professionals:
http://www.dailynewscentral.com


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